Publications: 2005

Arora, K., Gwinn, W.M., Bower, M.A., Watson, A., Okwumabua, I., MacDonald, H.R., Bukrinsky, M.I. and Constant, S.L. 2005. Extracellular cyclophilins contribute to the regulation of inflammatory responses. J. Immunol. 175:517-522.

Ayyoub, M., Merlo, A., Hesdorffer, C.S., Rimoldi, D., Speiser, D., Cerottini, J.-C., Chen, Y.-T., Old, L.J., Stevanovic, S. and Valmori, D. 2005. CD4+ T cell responses to SSX-4 in melanoma patients. J. Immunol. 174:5092-5099.

Ayyoub, M., Merlo, A., Hesdorffer, C.S., Speiser, D., Rimoldi, D., Cerottini, J.-C., Ritter, G., Chen, Y.-T., Old, L.J., Stevanovic, S. and Valmori, D. 2005. Distinct but overlapping T helper epitopes in the 37-58 region of SSX-2. Clin. Immunol. 114:70-78.

Bricard, G., Bouzourene, H., Martinet, O., Rimoldi, D., Halkic, N., Gillet, M., Chaubert, P., MacDonald, H.R., Romero, P., Cerottini, J.-C. and Speiser, D.E. 2005. Naturally acquired MAGE-A10- and SSX-2-specific CD8+ T cell responses in patients with hepatocellular carcinoma. J. Immunol. 174:1709-1716
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Cebecauer, M., Guillaume, P., Hozák, P., Mark, S., Everett, H., Schneider, P. and Luescher, I.F. 2005. Soluble MHC-peptide complexes induce rapid death of CD8+ CTL. J. Immunol. 174:6809-6819.

Cebecauer, M., Guillaume, P., Mark, S., Michielin, O., Boucheron, N., Bezard, M., Meyer, B.H., Segura, J.-M., Vogel, H. and Luescher, I.F. 2005. CD8+ cytotoxic T lymphocyte activation by soluble major histocompatibility complex-peptide dimers. J. Biol. Chem. 280:23820-23828.

Coudert, J.D., Zimmer, J., Tomasello, E., Cebecauer, M., Colonna, M., Vivier, E. and Held, W. 2005. Altered NKG2D function in NK cells induced by chronic exposure to NKG2D ligand-expressing tumor cells. Blood 106:1711-1717.

Croquelois, A., Blindenbacher, A., Terracciano, L., Wang, X., Langer, I., Radtke, F. and Heim, M.H. 2005. Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice. Hepatology 41:487-496.

Dumortier, A., Wilson, A., MacDonald, H.R. and Radtke, F. 2005. Paradigms of Notch signaling in mammals. Int. J. Hematol. 82:277-284.

Francis, J.C., Radtke, F. and Logan, M.P.O. 2005. Notch1 signals through jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud. Dev. Dyn. 234:1006-1015.

Gakamsky, D.M., Luescher, I.F., Pramanik, A., Kopito, R.B., Lemonnier, F., Vogel, H., Rigler, R. and Pecht, I. 2005. CD8 kinetically promotes ligand binding to the T-cell antigen receptor. Biophys. J. 89:2121-2133.

Germain, C., Larbouret, C., Cesson, V., Donda, A., Held, W., Mach, J.-P., Pèlegrin, A. and Robert, B. 2005. MHC class I-related chain a conjugated to antitumor antibodies can sensitize tumor cells to specific lysis by natural killer cells. Clin. Cancer Res. 11:7516-7522.

Goux, D., Coudert, J.D., Maurice, D., Scarpellino, L., Jeannet, G., Piccolo, S., Weston, K., Huelsken, J. and Held, W. 2005. Cooperating pre-T-cell receptor and TCF-1-dependent signals ensure thymocyte survival. Blood 106:1726-1733.

Held, W., Chalifour, A. and Coudert, J.D. 2005. Regulation of natural killer cell function: a role for the NK cell’s own MHC class I molecules. Med. Microbiol. Immunol. 194:169-174.

Kuball, J., Schmitz, F.W., Voss, R.-H., Ferreira, E. A., Engel, R., Guillaume, P., Strand, S., Romero, P., Huber, C., Sherman, L.A. and Theobald, M. 2005. Cooperation of human tumor-reactive CD4+ and CD8+ T cells after redirection of their specificity by a high-affinity p53A2.1-specific TCR. Immunity 22:117-129.

Le Gal, F.-A., Ayyoub, M., Dutoit, V., Widmer, V., Jäger, E., Cerottini, J.-C., Dietrich, P.-Y. and Valmori, D. 2005. Distinct structural TCR repertoires in naturally occurring versus vaccine-induced CD8+ T-cell responses to the tumor-specific antigen NY-ESO-1. J. Immunother. 28:252-257.

Lévy, F., Muehlethaler, K., Salvi, S., Peitrequin, A.-L., Lindholm, C.K., Cerottini, J.-C. and Rimoldi, D. 2005. Ubiquitylation of a melanosomal protein by HECT-E3 ligases serves as sorting signal for lysosomal degradation. Mol. Biol. Cell. 16:1777-1787.

Limbourg, F.P., Takeshita, K., Radtke, F., Bronson, R.T., Chin, M.T., and Liao, J.F. 2005. Essential role of endothelial Notch1 in angiogenesis. Circulation 111:1826-1832.

MacDonald, H.R. 2005. NK cell tolerance: revisiting the central dogma. Nat. Immunol. 6:868-869.

MacDonald, H.R. and Rolink, A.G. 2005. Lymphocyte development. Curr. Opin. Immunol. 17:97-99.

MacDonald, H.R. and Schümann, J. 2005. The need for natural killer T cells. Nat. Med. 11:256-257.

Mahnke, Y.D., Speiser, D., Luescher, I.F., Cerottini, J.-C. and Romero, P. 2005. Recent advances in tumour antigen-specific therapy: in vivo veritas. Int. J. Cancer 113:173-178.

Man, P., Novák, P. Cebecauer, M., Horváth, O., Fiserová, A., Havlicek, V. and Bezouska, K. 2005. Mass spectrometric analysis of the glycosphingolipid-enriched microdomains of rat natural killer cells. Proteomics 5:113-122.

Mancini, S.J.C., Mantei, N., Dumortier, A., Suter, U., MacDonald, H.R. and Radtke, F. 2005. Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood 105:2340-2342.

Michielin, O., Blanchet, J.-S., Fagerberg, T., Valmori, D., Rubio-Godoy, V., Speiser, D., Ayyoub, M., Alves, P., Luescher, I., Gairin, J.-E., Cerottini, J.-C. and Romero, P. 2005. Tinkering with nature: The tale of optimizing peptide based cancer vaccines. Cancer Treat. Res. 123:268-291.

Montes, M., Rufer, N., Appay, V., Reynard, S., Pittet, M.J., Speiser, D.E., Guillaume, P., Cerottini, J.-C., Romero, P. and Leyvraz, S. 2005. Optimum in vitro expansion of human antigen-specific CD8+ T cells for adoptive transfer therapy. Clin. Exp. Immunol. 142:292-302.

Murphy, M.J., Wilson, A. and Trumpp, A. 2005. More than just proliferation: Myc function in stem cells. Trends Cell Biol. 15:128-137.

Nyfeler, Y., Kirch, R.D., Mantei, N., Leone, D.P., Radtke, F., Suter, U. and Taylor, V. 2005. Jagged1 signals in the postnatal subventricular zone are required for neural stem cell self-renewal. EMBO 24:3504-3515.

Radtke, F. and Clevers, H. 2005. Self-renewal and cancer of the gut: Two sides of a coin. Science 307:1904-1909.

Radtke, F., Schweisguth, F. and Pear, W. 2005. The Notch “gospel”. EMBO rep. 6:1120-1125.

Radtke, F., Wilson, A. and MacDonald, H.R. 2005. Notch signaling in hematopoiesis and lymphopoiesis: lessons from Drosophila. BioEssays 27:1117-1128.

Romero. P., Cerottini, J.-C. and Luescher, I. 2005. On the significance of CD8aa expression for T cell memory. Eur. J. Immunol. 35:3092-3094.

Rufer, N., Reichenbach, P. and Romero, P. 2005. Methods for the ex vivo characterization of human CD8+ T subsets based on gene expression and replicative history analysis. Methods Mol. Med. 109:265-283.

Saleh, F., Renno, W., Klepacek, I., Ibrahim, G., Asfar, S., Dashti, H., Romero, P., Dashti, A., Behbehani, A. 2005. Melanoma immunotherapy: past, present and future. Curr. Pharm. Design 11:3461-3473.

Schümann, J., Pittoni, P., Tonti, E., MacDonald, H.R., Dellabona, P. and Casorati, G. 2005. Targeted expression of human CD1d in transgenic mice reveals independent roles for thymocytes and thymic APCs in positive and negative selection of Va14i NKT cells. J. Immunol. 175:7303-7310.

Schwarz, K., Meijerink, E., Speiser, D.E., Tissot, A.C., Cielens, I., Renhof, R., Dishlers, A., Pumpens, P. and Bachmann, M.F. 2005. Efficient homologous prime-boost strategies for T cell vaccination based on virus-like particles. Eur. J. Immunol. 35:816-821.

Slingluff, C.L. and Speiser, D.E. 2005. Progress and controversies in developing cancer vaccines. J. Transl. Med. [serial online] 3:18. URL:http://www.translational-medicine.com/content/3/1/18

Speiser, D.E. 2005. Ex vivo characterization of T cell-mediated immune responses in cancer. Curr. Opin. Immunol. 17:419-422.

Speiser, D.E., and Romero, P. 2005. Toward improved immunocompetence of adoptively transferred CD8+ T cells. J. Clin. Invest. 115:1467-1469.

Speiser, D.E., Cerottini, J.-C. and Romero, P. 2005. Tumor cell recognition efficiency by T cells. PLoS Med. 2:263-264.

Speiser, D.E., Liénard, D., Rufer, N., Rubio-Godoy, V., Rimoldi, D., Lejeune, F., Krieg, A.M., Cerottini, J.-C. and Romero, P. 2005. Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909. J. Clin. Invest. 115:739-746.

van Baren, N., Bonnet, M.-C., Dréno, B., Khammari, A., Dorval, T., Piperno-Neumann, S., Liénard, D., Speiser, D., Marchand, M., Brichard, V.G., Escudier, B., Négrier, S., Dietrich, P.-Y., Maraninchi, D., Osanto, S., Meyer, R.G., Ritter, G., Moingeon, P., Tartaglia, J., van der Bruggen, P., Coulie, P.G. and Boon, T. 2005. Tumoral and immunologic response after vaccination of melanoma patients with an ALVAC virus encoding MAGE antigens recognized by T cells. J. Clin. Oncol. 23:9008-9021.

van Es, J.H., van Gijn, M.E., Riccio, O., van den Born, M., Vooijs, M., Begthel, H., Cozijnsen, M., Robine, S., Winton, D.J., Radtke, F. and Clevers, H. 2005. Notch/g-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 435:959-963.

van Houdt, I.S., Oudejans, J.J., van den Eertwegh, A.J.M., Baars, A., Vos, W., Bladergroen, B.A., Rimoldi, D., Muris, J.J.F., Hooijberg, E., Gundy, C.M., Meijer, C.J.L.M., and Kummer, J.A. 2005. Expression of the apoptosis inhibitor protease inhibitor 9 predicts clinical outcome in vaccinated patients with stage III and IV melanoma. Clin. Cancer Res. 11:6400-6407.

Vauclair, S., Nicolas, M., Barrandon, Y. and Radtke, F. 2005. Notch1 is essential for postnatal hair follicle development and homeostasis. Dev. Biol. 284:184-193.

Walter, S., Bioley, G., Bühring, H.-J., Koch, S., Wernet, D., Zippelius, A., Pawelec, G., Romero, P., Stevanovic, S., Rammensee, H.-G. and Gouttefangeas, C. 2005. High frequencies of functionally impaired cytokeratin 18-specific CD8+ T cells in healthy HLA-A2+ donors. Eur. J. Immunol. 35:2876-2885.