Publications: 2006

Angelov, G.S., Guillaume, P., Cebecauer, M., Bosshard, G., Dojcinovic, D., Baumgaertner, P. and Luescher, I.F. 2006. Soluble MHC-peptide complexes containing long rigid linkers abolish CTL-mediated cytotoxicity. J. Immunol. 176:3356-3365.

Appay, V., Jandus, C., Voelter, V., Reynard, S., Coupland, S.E., Rimoldi, D., Liénard, D., Guillaume, P., Krieg, A.M., Cerottini, J.-C., Romero, P., Leyvraz, S., Rufer, N. and Speiser, D.E. 2006. New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site. J. Immunol.177:1670-1678.

Appay, V., Reynard, S., Voelter, V., Romero, P., Speiser, D.E. and Leyvraz, S. 2006. Immuno-monitoring of CD8+ T cells in whole blood versus PBMC samples. J. Immunol. Methods 309:192-199.

Appay, V., Speiser, D.E., Rufer, N., Reynard, S., Barbey, C., Cerottini, J.-C., Leyvraz, S., Pinilla, C. and Romero, P. 2006. Decreased specific CD8+ T cell cross-reactivity of antigen recognition following vaccination with Melan-A peptide. Eur. J. Immunol. 36:1805-1814.

Aublin, A., Ciofani, M., Willkomm, N., Hamrouni, A., Szymczak-Workman, A.L., Takahashi, T., Sandjeu, Y., Guillaume, P., Vignali, D.A.A., Michielin, O., Zúñiga-Pflücker, J.C. and Maryanski, J.L. 2006. A natural structural variant of the mouse TCR ß-chain displays intrinsic receptor function and antigen specificity. J. Immunol. 177:8587-8594.

Batard, P., Peterson, D.A., Devêvre, E., Guillaume, P., Cerottini, J.-C., Rimoldi, D., Speiser, D.E., Winther, L. and Romero, P. 2006. Dextramers: new generation of fluorescent MHC class I/peptide multimers for visualization of antigen-specific CD8+ T cells. J. Immunol. Methods. 310:136-148.

Baumgaertner, P., Rufer, N., Devêvre, E., Derré, L., Rimoldi, D., Geldhof, C., Voelter, V., Liénard, D., Romero, P. and Speiser, D.E. 2006. Ex vivo detectable human CD8 T-cell responses to cancer-testis antigens. Cancer Res. 66:1912-1916.
Bianchi, T., Gasser, S., Trumpp, A. and MacDonald, H.R. 2006. c-Myc acts downstream of IL-15 in the regulation of memory CD8 T-cell homeostasis. Blood 107:3992-3999.

Bianchi, T., Rufer, N., MacDonald, H.R. and Migliaccio, M. 2006. The tumor suppressor p16Ink4a regulates T lymphocyte survival. Oncogene 25:4110-4115.

Bioley, G., Jandus, C., Tuyaerts, S., Rimoldi, D., Kwok, W.W., Speiser, D.E., Tiercy, J.-M., Thielemans, K., Cerottini, J.-C. and Romero, P. 2006. Melan-A/MART-1-specific CD4 T cells in melanoma patients: identification of new epitopes and ex vivo visualization of specific T cells by MHC class II tetramers. J. Immunol. 177:6769-6779.

Bron, L. and Romero, P. 2006. L’immunothérapie des carcinomes épidermoïdes de la sphère ORL. Rev. Med. Suisse 2 :2216-2219.

Capendeguy, O., Chodanowski, P., Michielin, O. and Horisberger, J.-D. 2006. Access of extracellular cations to their binding sites in Na, K-ATPase: role of the second extracellular loop of the ? subunit. J. Gen. Physiol. 127:341-352.

Cesson, V., Stirnemann, K., Robert, B., Luescher, I., Filleron, T., Corradin, G., Mach, J.-P. and Donda, A. 2006. Active antiviral T-lymphocyte response can be redirected against tumor cells by antitumor antibody × MHC/viral peptide conjugates. Clin. Cancer Res. 12:7422-7430.

Chapatte, L., Ayyoub, M., Morel, S., Peitrequin, A.-L., Lévy, N., Servis, C., Van den Eynde, B.J., Valmori, D. and Lévy, F. 2006. Processing of tumor-associated antigen by the proteasomes of dendritic cells controls in vivo T-cell responses. Cancer Res. 66:5461-5468.

Chapatte, L., Colombetti, S., Cerottini, J.-C. and Lévy, F. 2006. Efficient induction of tumor antigen-specific CD8+ memory T cells by recombinant lentivectors. Cancer Res. 66:1155-1160.

Colombetti, S., Fagerberg, T., Baumgärtner, P., Chapatte, L., Speiser, D.E., Rufer, N., Michielin, O. and Lévy, F. 2006. Impact of orthologous Melan-A peptide immunizations on the anti-self Melan-A/HLA-A2 T cell cross-reactivity. J. Immunol. 176:6560-6567.

Coudert, J.D. and Held W. 2006. The role of the NKG2D receptor for tumor immunity. Semin. Cancer Biol. 16:333-343.

Devêvre, E., Romero, P. and Mahnke, Y.D. 2006. LiveCount Assay: concomitant measurement of cytolytic activity and phenotypic characterisation of CD8+ T-cells by flow cytometry. J. Immunol. Methods 311:31-46.

Didierlaurent, A., Brissoni, B., Velin, D., Aebi, N., Tardivel, A., Käslin, E., Sirard, J.C., Angelov, G., Tschopp, J. and Burns, K. 2006. Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide. Mol. Cell. Biol. 26:735-742.

Fagerberg, T., Cerottini, J.-C. and Michielin, O. 2006. Structural prediction of peptides bound to MHC class I. J. Mol. Biol. 356:521-546.

Ferreira, C., Furmanski, A., Millrain, M., Bartok, I., Guillaume, P., Lees, R., Simpson, E., MacDonald, H.R. and Dyson, J. 2006. TCR-? CDR3 loop audition regulates positive selection. J. Immunol. 177:2477-2485.

Ferrero, I., Mancini, S.J.C., Grosjean, F., Wilson, A., Otten, L. and MacDonald, H.R. 2006. TCR? silencing during aß T cell development depends upon pre-TCR- induced proliferation. J. Immunol. 177:6038-6043.

Guillaume, P., Baumgaertner, P., Agelov, G.S., Speiser, D.E., and Luescher, I.F. 2006. Fluorescence-activated cell sorting and cloning of bona fide CD8+ CTL with reversible MHC-peptide and antibody Fab’ conjugates. J. Immunol. 177:3903-3912.

Gumy, A., Aseffa, A., Breton, Rachinel, N., Breton, M., M., Otten, L., Tacchini-Cottier, F., Röcken, M., Doyen, N., Acha-Orbea, H., Locksley, R.M., MacDonald, H.R., Launois, P., and Louis, J. 2006. LACK-reactive CD4+ T cells require autocrine IL-2 to mediate susceptibility to Leishmania major. Eur. J. Immunol. 36:1465-1473.

Huang, Z., Xie, H., Ioannidis, V., Held, W., Clevers, H., Sadim, M.S. and Sun, Z. 2006. Transcriptional regulation of CD4 gene expression by T cell factor-1/?-catenin pathway. J. Immunol. 176:4880-4887.

Jackson, H., Dimopoulos, N, Mifsud, N.A., Tai, T.Y., Chen, Q., Svobodova, S., Browning, J., Luescher, I., Stockert, L, Old, L.J., Davis, I.D., Cebon, J. and Chen, W. 2006. Striking immunodominance hierarchy of naturally occurring CD8+ and CD4+ T cell responses to tumor antigen NY-ESO-1. J. Immunol. 176:5908-5917.

Jeannet, G., Coudert, J.D., and Held, W. 2006. T and B lymphocytes exert distinct effects on the homeostasis of NK cells. Eur. J. Immunol. 36:2725-2734.

Lejeune, F.J., Liénard, D., Matter, M. and Rüegg, C. 2006. Efficiency of recombinant human TNF in human cancer therapy. Cancer Immun. [serial online] 6:6. URL: http://www.cancerimmunity.org/v6p6/060105.htm

Lévy, F. and Colombetti, S. 2006. Promises and limitations of murine models in the development of anticancer T-cell vaccines. Int. Rev. Immunol. 25:269-295.

Migliaccio, M., Alves, P.M.S., Romero, P. and Rufer, N. 2006. Distinct mechanisms control human naive and antigen-experienced CD8+ T lymphocyte proliferation. J. Immunol. 176:2173-2182.

Nemir, M., Croquelois, A., Pedrazzini, T. and Radtke, F. 2006. Induction of cardiogenesis in embryonic stem cells via downregulation of Notch1 signaling. Circ. Res. 98:1471-1478.

Pittet, M.J., Gati, A., Le Gal, F.-A., Bioley, G., Guillaume, P., de Semdt, M., Plum, J., Speiser, D.E., Cerottini, J.-C., Dietrich, P.-Y., Romero, P. and Zippelius, A. 2006. Ex vivo characterization of Allo-MHC-restricted T cells specific for a single MHC-peptide complex. J. Immunol. 176:2330-2336.

Radtke, F., Clevers, H. and Riccio, O. 2006. From gut homeostasis to cancer. Curr. Mol. Med. 6:275-289.

Romero P., Cerottini, J.-C. and Speiser, D.E. 2006. The human T cell response to melanoma antigens. Adv. Immunol. 92:187-209.

Schümann, J., Mycko, M.P., Dellabona, P., Casorati, G. and MacDonald, H.R. 2006. Cutting Edge: Influence of the TCR V? domain on the selection of semi-invariant NKT cells by endogenous ligands. J. Immunol. 176:2064-2068.

Speiser, D.E., Baumgaertner, P., Barbey, C., Rubio-Godoy, V., Moulin, A., Corthesy, P., Devêvre, E., Dietrich, P.-Y., Rimoldi, D., Liénard, D., Cerottini, J.-C., Romero, P. and Rufer, N. 2006. A novel approach to characterize clonality and differentiation of human melanoma-specific T cell responses: spontaneous priming and efficient boosting by vaccination. J. Immunol. 177:1338-1348.

Tabiasco, J., Devêvre, E., Rufer, N., Salaun, B., Cerottini, J.-C., Speiser, D.E. and Romero, P. 2006. Human effector CD8+ T lymphocytes express toll like receptor-3 as a functional coreceptor. J. Immunol. 177:8708-8713.

Viatte, S., Alves, P.M. and Romero, P. 2006. Reverse immunology approach for the identification of CD8 T-cell-defined antigens: advantages and hurdles. Immunol. Cell Biol. 84:318-330.

Voss, R.-H., Kuball, J., Engel, R., Guillaume, P., Romero, P., Huber, C., Theobald, M. 2006. Redirection of T cells by delivering a transgenic mouse-derived MDM2 tumor antigen-specific TCR and its humanized derivative is governed by the CD8 coreceptor and affects natural human TCR expression. Immunol. Res. 34:67-87.

Walton, S.M., Gerlinger, M., de la Rosa, O., Nuber, N., Knights, A., Gati, A., Laumer, M., Strauss, L., Exner, C., Schäfer, N., Urosevic, M., Dummer, R., Tiercy, J.-M., Mackensen, A., Jaeger, E., Lévy, F., Knuth, A., Jäger, D. and Zippelius, A. 2006. Spontaneous CD8 T cell responses against the melanocyte differentiation antigen RAB38/NY-MEL-1 in melanoma patients. J. Immunol. 177: 8212-8218.

Wang, X.-D., Leow, C.C., Zha, J., Tang, Z., Modrusan, Z., Radtke, F., Aguet, M., de Sauvage, F.J. and Gao, W.-Q. 2006. Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation. Dev. Biol. 290:66-80.

Wilson, A. and Radtke, F. 2006. Multiple functions of Notch signaling in self-renewing organs and cancer. FEBS Lett. 580:2860-2868.

Wilson, A. and Trumpp, A. 2006. Bone-marrow haematopoietic-stem-cell niches. Nat. Rev. Immunol. 6:93-106.

Yip, Y.L., Zoete, V., Scheib, H. and Michielin, O. 2006. Structural assessment of single amino acid mutations: application to TP53 function. Hum. Mutat. 27:926-937.