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| Publications:
2007 |
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Alves, P.M.S.,
Lévy, N., Bouzourene, H., Viatte, S., Bricard,
G., Ayyoub, M., Vuilleumier, H., Givel, J.-C. R., Halkic, N.,
Speiser, D.E., Romero, P. and Lévy, F.
2007. Molecular and immunological evaluation of the expression
of cancer/testis gene products in human colorectal cancer. Cancer Immunol.
Immunother. 56:839-847.
Alves, P.M.S., Viatte, S., Fagerberg, T., Michielin,
O., Bricard, G., Bouzourene, H., Vuilleumier, H., Kruger,
T., Givel, J.-C., Lévy, F., Speiser, D.E., Cerottini, J.-C.
and Romero, P. 2007. Immunogenicity of the carcinoembryonic
antigen derived peptide 694 in HLA-A2 healthy donors and colorectal carcinoma
patients. Cancer Immunol. Immunother. 56:1795-1805.
Appay, V., Bosio, A., Lokan, S., Wiencek, Y., Biervert, C., Kürsters,
D., Devêvre, E., Speiser, D., Romero, P., Rufer,
N. and Leyvraz, S. 2007. Sensitive gene expression profiling of human
T cell subsets reveals parallel post-thymic differentiation for CD4+ and
CD8+ lineages. J. Immunol. 179:7406-7414.
Appay, V., Voelter, V., Rufer, N., Reynard, S., Jandus, C.,
Gasparini, D., Liénard, D., Speiser, D.E., Schneider,
P., Cerottini, J.-C., Romero, P. and Leyvraz, S. 2007.
Combination of transient lymphodepletion with Busulfan and Fludarabine
and peptide vaccination in a phase I clinical trial for patients with
advanced melanoma. J. Immunother. 30:240-250.
Back, J., Chalifour, A., Scarpellino, L. and
Held, W. 2007. Stable masking by H-2Dd cis ligand limits Ly49A
relocalization to the site of NK cell/target cells contact. PNAS 104:3978-3983.
Barbey, C., Baumgaertner, P., Devêvre, E., Rubio-Godoy,
V., Derré, L., Bricard, G., Guillaume, P., Luescher, I.F., Liénard,
D., Cerottini, J.-C., Romero, P., Rufer, N., and Speiser,
D.E. 2007. Il-12 controls cytotoxicity of a novel subset of self-antigen-specific
human CD28+ cytolytic T cells. J. Immunol. 178:3566-3574.
Besseyrias, V., Fiorini, E., Strobl, L.J., Zimber-Strobl,
U., Dumortier, A., Koch, U., Arcangeli, M.-L., Ezine, S., MacDonald,
H.R. and Radtke, F. 2007. Hierarchy of Notch-Delta
interactions promoting T cell lineage commitment and maturation. J. Exp.
Med. 204:331-343.
Bron, L. and Romero, P. 2007. Immunotherapy: a new alternative
treatment for head and neck squamous cell carcinoma. Bull. Cancer 94:793-797.
Butticaz, C., Michielin, O., Wyniger, J., Telenti, A.
and Rothenberger, S. 2007. Silencing of both ß-TrCP1 and HOS (ß-TrCP2)
is required to suppress human immunodeficiency virus type 1 Vpu-mediated
CD4 down-modulation. J. Virol. 81:1502-1505.
Chen, J., Schmitt, A., Chen, B., Rojewski, M., Ringhoffer, M., von Harsdorf,
S., Greiner, J., Guillaume, P., Döhner, H., Bunjes,
D. and Schmitt, M. 2007. Imatinib impairs CD8+ T lymphocytes specifically
directed against the leukemia-associated antigen RHAMM/CD168 in vitro.
Cancer Immunol. Immunother. 56:849-861.
De Libero, G., MacDonald, H.R. and Dellabona, P. 2007.
T cell recognition of lipids: quo vadis? Nat. Immunol. 8:223-227.
Derré, L., Bruyninx, M., Baumgaertner, P., Devêvre, E., Corthesy,
P., Touvrey, C., Mahnke, Y.D., Pircher, H., Voelter, V., Romero, P., Speiser,
D.E. and Rufer, N. 2007. In vivo persistence of codominant human CD8+
T cell clonotypes is not limited by replicative senescence or functional
alteration. J. Immunol. 179:2368-2379.
Derré,
L., Bruyninx, M., Baumgaertner, P., Devêvre, E., Corthesy,
P., Touvrey, C., Mahnke, Y.D., Pircher, H., Voelter,
V., Romero, P., Speiser, D.E. and Rufer, N. 2007. In
vivo persistence of codominant human CD8+ T cell clonotypes is not limited
by replicative senescence or functional alteration. J. Immunol. 179:2368-2379.
Derré, L., Ferber, M., Touvrey, C., Devêvre,
E., Zoete, V., Leimgruber, A., Romero, P., Michielin,
O., Lévy, F. and Speiser, D.E. 2007.
A novel population of human melanoma-specific CD8 T cells recognizes Melan-AMART-1
immunodominant nonapeptide but not the corresponding decapeptide. J. Immunol.
179:7635-7645.
Elliott, B., Scolyer, R.A., Suciu, S., Lebecque, S., Rimoldi,
D., Gugerli, O., Musat, E., Sharma, R.N., Liénard, D.,
Keilholz, U., Testori, A., Eggermont, A., MacKie, R., Robert, C., Cook,
M., Thompson, J.F. Angevin, E. and Spatz, A. on behalf of the European
Organization for Research and Treatment of Cancer Melanoma Group. 2007.
Long-term protective effect of mature DC-LAMP+ dendritic cell accumulation
in sentinel lymph nodes containing micrometastatic melanoma. Clin. Cancer
Res. 13:3825-3830.
Feige, J.N., Gelman, L., Rossi, D., Zoete, V., Métivier, R., Tudor,
C., Anghel, S.I., Grosdidier, A., Lathion, C., Engelborghs,
Y., Michielin, O., Wahli, W. and Desvergne, B. 2007.
The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome
proliferator-activated receptor ? modulator that promotes adipogenesis.
J. Bio. Chem. 282:19152-19166.
Ferrero, I., Grosjean, F. Fiorini, E. and MacDonald,
H.R. 2007. A critical lineage-nonspecific role for pTa in mediating
allelic and isotypic exclusion in TCRß-transgenic mice. Eur. J.
Immunol. 37:3220-3228.
Ferrero, I., Michielin, O., and Luescher, I.
2007. Antigen recognition by T lymphocytes. Encyclopedia of Life
Sciences, John Wiley & Sons, Ltd. www.els.net
Held, G., Wadle, A., Dauth, N., Stewart-Jones, G., Sturm, C., Thiel, M.,
Zwick, C., Dieckmann, D., Schuler, G., Hoogenboom, H.R., Lévy,
F., Cerundolo, V., Pfreunsdschuh, M. and Renner, C. 2007. MHC-peptide-specific
antibodies reveal inefficient presentation of an HLA-A*0201-restricted,
Melan-A-derived peptide after active intracellular processing. Eur. J.
Immunol. 37:2008-2017.
Iero, M. Squarcina, P., Romero, P., Guillaume, P., Scarselli,
E., Cerino, R., Carrabba, M., Toutirais, O., Parmiani, G. and Rivoltini,
L. 2007. Low TCR avidity and lack of tumor cell recognition in CD8+ T
cells primed with the CEA-analogue CAP1-6D peptide. Cancer Immunol. Immunother.
56:1979-1991.
Jorritsma, A., Gomez-Eerland, R., Dokter, M., van de Kasteele, W., Zoet,
Y.M., Doxiadis, I.I., Rufer, N., Romero, P., Morgan,
R.A., Schumacher, T.N. and Haanen, J.B. 2007. Selecting highly affine
and well-expressed TCRs for gene therapy of melanoma. Blood 110:3564-3572.
Kelly, A.P., Finlay, D.K., Hinton, H.J., Clarke, R.G., Fiorini,
E., Radtke, F. and Cantrell, D.A. 2007. Notch-induced T cell
development requires phosphoinositide-dependent kinase 1. EMBO J. 26:3441-3450.
Le Gal, F.-A., Widmer, V.M., Dutoit, V., Rubio-Godoy, V.,
Schrenzel, J., Walker, P.R., Romero, P., Valmori, D., Speiser,
D.E. and Dietrich, P.V. 2007. Tissue homing and persistence of
defined antigen-specific CD8+ tumor-reactive T-cell clones in long-term
melanoma survivors. J. Invest. Dermat. 127:622-629.
Lejeune, F., Rimoldi, D. and Speiser, D.E.
2007. New approaches in metastatic melanoma: biological and molecular
targeted therapies. Expert Rev. Anticancer Ther. 7:701-713.
MacDonald, H.R. 2007. NKT cells: in the beginning…Eur.
J. Immunol. 37:S111-115.
MacDonald, H.R. and Mycko, M.P. 2007.
Development and selection of Va14i NKT cells. Curr. Top. Microbiol. Immunol.
314:195-212.
Meijer, S.L., Dols, A., Jensen, S.M., Hu, H.-M., Miller, W., Walker, E.,
Romero, P., Fox, B.A. and Urba, W.J. 2007. Induction
of circulating tumor-reactive CD8+ T cells after vaccination of melanoma
patients with the gp100209-2M peptide. J. Immunother. 30:533-543.
Melichar, H.J., Narayan, K., Der, S.D., Hiraoka, Y., Gardiol,
N., Jeannet, G., Held, W., Chambers, C.A. and Kang, J. 2007.
Regulation of ?d versus ?ß T lymphocyte differentiation by the transcription
factor SOX13. Science 315:230-233.
Michalik, L., Zoete, V., Krey, G., Grosdidier, A., Gelman,
L., Chodanowski, P., Feige, J.N., Desvergne, B., Wahli, W. and Michielin,
O. 2007. Combined simulation and mutagenesis analyses reveal
the involvement of key residues for peroxisome proliferator-activated
receptor ? Helix 12 dynamic behavior. J. Biol. Chem. 282:9666-9677.
Minguet, S., Swamy, M., Alarcón, B., Luescher, I.F.
and Schamel, W.W.A. 2007. Full activation of the T cell receptor requires
both clustering and conformational changes at CD3. Immunity 26:43-54.
Naeher, D., Daniels, M.A., Hausmann, B., Guillaume, P., Luescher,
I. and Palmer, E. 2007. A constant affinity threshold for T cell
tolerance. J. Exp. Med. 204:2553-2559.
Pittet, M.J., Grimm, J., Berger, C.R., Tamura, T., Wojtkiewicz, G., Nahrendorf,
M., Romero, P., Swirski, F.K. and Weissleder, R. 2007.
In vivo imaging of T cell delivery to tumors after adoptive transfer therapy.
Proc. Natl. Aca. Sci. USA 104:12457-12461.
Romero, P. and Speiser, D.E. 2007. Perspectives and limitations of vaccination
strategies against cancer. Cell. Immunother. and Vaccination 1:270-277.
Romero, P. and Speiser, D.E. 2007. Perspectives
and limitations of vaccination strategies against cancer. Cell. Immunother.
and Vaccination 1:270-277.
Romero, P., Zippelius, A., Kurth, I., Pittet,
M.J., Touvrey, C., Iancu, E.M., Corthesy, P., Devêvre,
E., Speiser, D.E. and Rufer, N. 2007. Four functionally distinct
populations of human effector-memory CD8+ T lymphocytes. J. Immunol. 178:4112-4119.
Salaun, B., Lebecque, S., Matikainen, S., Rimoldi,
D. and Romero, P. 2007. Toll-like receptor 3
expressed by melanoma cells as a target for therapy? Clin. Cancer Res.
13:4565-4574.
Salaun, B., Romero, P. and Lebecque, S. 2007. Toll-like
receptors two-edged sword: when immunity meets apoptosis. Eur. J. Immunol.
37:3311-3318.
Scarpellino, L., Oeschger, F., Guillaume, P.,
Coudert, J.D., Lévy, F., Leclercq, G. and Held,
W. 2007. Interactions of Ly49 family receptors with MHC class
I ligands in trans and cis. J. Immunol. 178:1277-1284.
Schmitz-Winnenthal, F.H., Galindo-Escobedo, L.V., Rimoldi, D.,
Geng, W., Romero, P., Koch, M., Weitz, J., Krempien,
R., Niethammer, A.G., Beckhove, P., Buchler, M.W. and Z’graggen,
K. 2007. Potential target antigens for immunotherapy in human pancreatic
cancer. Cancer Lett. 252:290-298.
Takeshita, K., Satoh, M., Ili, M., Silver, M., Limbourg, F.P., Mukai,
Y., Rikitake, Y., Radtke, F., Gridley, T., Losordo, D.W.
and Liao, J.K. 2007. Critical role of endothelial Notch1 signaling in
postnatal angiogenesis. Circ. Res. 100:70-78.
Valmori, D., Lévy, F., Godefroy, E., Scotto, L.,
Souleimanian, N.E., Karbach, J., Tosello, V., Hesdorffer, C.S., Old, L.J.,
Jager, E. and Ayyoub, M. 2007. Epitope clustering in regions undergoing
efficient proteasomal processing defines immunodominant CTL regions of
a tumor antigen. Clin. Immunol. 122:163-172.
Willi, J.-P., Matter, M., Buchegger, F., Antonescu, C., Guggisberg, D.,
Cerottini, J.-P., Krischer, J., Braun, R., Kurt, A.M., Roche, B., Lemoine,
R., Rimoldi, D., Lejeune, F.J., Liénard, D., Bischof
Delaloye, A. and the Groupe Mélanome Lémanique. 2007. Sentinel
lymph node involvement and a high breslow index are independent factors
of risk for early relapse of melanoma. Nuklearmedizin 46:244-251.
Wilson, A., Ardiet, D.-L., Saner, C., Vilain, N., Beermann,
F., Aguet, M., MacDonald, H.R. and Zilian, O. 2007. Normal
hemopoiesis and lymphopoiesis in the combined absence of Numb and Numblike.
J. Immunol. 178:6746-6751.
Wilson, A., Oser, G.M., Jaworski, M., Blanco-Bose, W.E., Laurenti, E.,
Adolphe, C., Essers, M.A., MacDonald, H.R. and Trumpp, A. 2007. Dormant
and self-renewing hematopoietic stem cells and their niches. Ann. N.Y.
Acad. Sci. 1106:64-75.
Wilson, A.,
Oser, G.M., Jaworski, M., Blanco-Bose, W.E., Laurenti, E., Adolphe, C.,
Essers, M.A., MacDonald, H.R. and Trumpp, A. 2007. Dormant
and self-renewing hematopoietic stem cells and their niches. Ann. N.Y.
Acad. Sci. 1106:64-75.
Zhang, S.-Y., Jouanguy, E., Ugolini, S., Smahi, A., Elain, G., Romero,
P., Segal, D., Sancho-Shimizu, V., Lorenzo, L., Puel, A., Picard,
C., Chapgier, A., Plancoulaine, S., Titeux, M., Cognet, C., von Bernuth,
H., Ku, C.-L., Casrouge, A., Zhang, X.-X., Barreiro, L., Leonard, J.,
Hamilton, C., Lebon, P., Héron, B., Vallée, L., Quintana-Murci,
L., Hovnanian, A., Rozenberg, F., Vivier, E., Geissmann, F., Tardieu,
M., Abel, L. and Casanova, J.-L. 2007. TLR3 deficiency inpatients with
herpes simplex encephalitis. Science 317:1522-1527.
Zoete, V. and Michielin, O. 2007. Comparison between
computational alanine scanning and per-residue binding free energy decomposition
for protein-protein association using MM-GBSA: application to the TCR-p-MHC
complex. Proteins 67:1026-1047.
Zoete, V., Grosdidier, A. and Michielin, O. 2007. Peroxisome
proliferator-activated receptor structures: ligand specificity, molecular
switch and interactions with regulators. Biochim. Biophys. 1771:915-925.
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